esophagitis

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	208
interventional	146
Observational	56
Registry	6

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	70
Drug|placebo	39
Device	11
Other	6
Drug|Other	3
Procedure	3
Behavioral	1
Behavioral|Drug	1
Behavioral|Drug|placebo	1
Biological	1
Biological|Other	1
Combination Product	1
Device|Drug|Procedure	1
Device|Other	1
Device|Procedure	1
Diagnostic Test|Drug|Other|placebo	1
Dietary Supplement|Other	1
Drug|Procedure	1
Drug|Procedure|Radiation	1
Other|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	73
Japan	15
Korea, Republic of	10
NA	7
United Kingdom	6
Switzerland	4
Germany	3
China	2
China|Korea, Republic of|Malaysia|Taiwan	2
Russian Federation	2
Taiwan	2
United States|Canada	2
United States|Canada|Denmark|Finland|France|Germany|Italy|Norway|Sweden|United Kingdom	2
China|Korea, Republic of	1
Denmark|Finland|Norway|Sweden	1
Germany|Hungary|United States|Australia|Bulgaria|Canada|Czech Republic|India|Latvia|Lithuania|New Zealand|Peru|Poland|Slovakia|South Africa	1
Greece	1
Italy	1
Spain	1
United States|Australia|Belgium|Canada|France|Germany|Italy|Netherlands|Spain|United Kingdom	1
United States|Australia|Bulgaria|Canada|Colombia|Czech Republic|Germany|India|Latvia|Lithuania|New Zealand|Peru|Poland|Russian Federation|Slovakia|South Africa	1
United States|Australia|Canada|Czech Republic|Estonia|Latvia|Lithuania|Slovakia	1
United States|Australia|Canada|United Kingdom	1
United States|Australia|Netherlands	1
United States|Belgium|Brazil|Hungary|Italy|Mexico|Poland|Portugal	1
United States|Belgium|Canada|Germany|Spain|Switzerland	1
United States|Belgium|France|Italy	1
United States|Bulgaria|Czechia	1
United States|Canada|Switzerland	1

Sites per Study

Site_count	Study_Count
1	89
2	4
3	1
4	3
5	2
6	1
7	1
8	1
9	2
11	1
13	1
14	1
15	1
17	1
19	1
20	1
23	1
24	1
29	1
30	1
32	2
36	3
37	2
39	1
41	1
44	1
45	1
54	1
56	1
59	1
61	2
62	1
63	1
64	1
72	1
75	1
77	1
81	1
94	1
96	1
98	1
100	1
140	1
144	1
202	2

Phase

Phase	Study_Count
Phase 3	38
N/A	32
Phase 2	32
Phase 4	21
Phase 1	13
Phase 2/Phase 3	6
Early Phase 1	2
Phase 1/Phase 2	2

Number of Arms

Number_of_Arms	Count_of_Studies
1	35
2	54
3	23
4	12
5	5
NA	17

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	3.0	5.00000	8.00000	24	10.0000	51.0000	19.0000	3.0000
1st Qu.	6.5	20.50000	19.00000	24	31.0000	82.5000	192.5000	64.0000
Median	10.0	30.00000	22.00000	24	72.0000	178.0000	303.5000	100.0000
Mean	10.0	68.67742	28.38462	24	194.2258	185.1667	432.1579	180.9048
3rd Qu.	13.5	78.00000	41.00000	24	118.0000	281.7500	473.5000	143.0000
Max.	17.0	500.00000	49.00000	24	1400.0000	337.0000	2054.0000	1000.0000

Trial Group Type

group_type	Group_Count
Experimental	174
Active Comparator	63
Placebo Comparator	35
NA	17
Other	11
No Intervention	1
Sham Comparator	1

Intervention Model

intervention_model	Study_Count
Parallel Assignment	91
Single Group Assignment	41
Crossover Assignment	10
NA	2
Factorial Assignment	1
Sequential Assignment	1

Primary Purpose

primary_purpose	Study_Count
Treatment	108
Basic Science	10
Diagnostic	7
Supportive Care	6
Other	5
Prevention	5
NA	3
Device Feasibility	1
Screening	1

Observational Studies

Studies by Country

Country	Study_Count
United States	37
Japan	6
NA	3
Korea, Republic of	2
Switzerland	2
Austria|Italy|Norway|Spain|Sweden	1
Brazil	1
Finland|Romania	1
Israel|Italy	1
Thailand	1
United Kingdom	1

Sites per Study

Site_count	Study_Count
1	42
2	1
3	1
5	1
6	3
7	1
8	1
18	1
46	1
47	2
66	1
447	1

Enrollment Metrics

Measure	Observational
Min	10.000
1st Qu	55.500
Median	162.000
Mean	2001.339
3rd Qu	862.500
Max	61864.000

Observation Model

observational_model	Study_Count
Cohort	27
Case-Only	10
Case-Control	8
Other	6
NA	3
Case Control	2

Time Perspective

time_perspective	Study_Count
Prospective	46
Retrospective	5
Other	3
Cross-Sectional	2

Registries

Studies by Country

Country	Study_Count
United States	4
NA	1
Spain	1

Sites per Study

Site_count	Study_Count
1	4
2	2

Enrollment Metrics

Measure	Registries
Min	70.0000
1st Qu	91.0000
Median	100.0000
Mean	309.6667
3rd Qu	400.0000
Max	1000.0000

Registry Model

observational_model	Study_Count
Case-Only	3
Cohort	2
Case-Control	1

Time Perspective

time_perspective	Study_Count
Prospective	5
Cross-Sectional	1

Follow-up

target_duration	Study_Count
5 Years	2
1 Day	1
1 Year	1
2 Days	1
2 Years	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03078023	Sponge and Eosinophil Peroxidase (EPO) Staining	https://ClinicalTrials.gov/show/NCT03078023	Recruiting	Mayo Clinic	2021-03-01
NCT04322708	A Study of Antolimab (AK002) in Patients With Active Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT04322708	Recruiting	Allakos, Inc.	2021-12-31
NCT03633617	Study to Determine the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT03633617	Recruiting	Regeneron Pharmaceuticals	2022-04-22
NCT03553563	A Study of Esomeplazole (D961H) in Japanese Paediatric Patients With Reflux Esophagitis, Gastric Ulcer or Duodenal Ulcer	https://ClinicalTrials.gov/show/NCT03553563	Recruiting	AstraZeneca	2023-01-04
NCT01597674	Effect of 5, 10 or 25 mg of YF476 Daily for 14 Days on Stomach Acidity in Healthy Volunteers	https://ClinicalTrials.gov/show/NCT01597674	Completed	Trio Medicines Ltd.	1997-06-30
NCT03342391	CEGIR 7808: Use of Unsedated Transnasal Esophagoscopy (TNE) to Monitor Dietary Management of Eosinophilic Esophagitis in Children	https://ClinicalTrials.gov/show/NCT03342391	Recruiting	Children’s Hospital Medical Center, Cincinnati	2020-07-31
NCT03305653	Use of Esophageal String Test to Understand Symptoms, Inflammation, and Function in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT03305653	Recruiting	University of Colorado, Denver	2020-12-31
NCT03228147	Sensory Evaluation of Oral Nutrition Supplements in Patients at Risk for Mucositis Undergoing Cancer Treatment	https://ClinicalTrials.gov/show/NCT03228147	Completed	Rutgers, The State University of New Jersey	2017-10-31
NCT03191864	Efficacy, Safety, and Pharmacokinetics of APT-1011 in Subjects With Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT03191864	Active, not recruiting	Adare Pharmaceuticals, Inc.	2019-11-08
NCT03116841	Vonoprazan Study of Investigating the Effect on Sleep Disturbance Associated With Reflux Esophagitis- Exploratory Evaluation	https://ClinicalTrials.gov/show/NCT03116841	Completed	Takeda	2017-12-20
NCT03029091	An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT03029091	Completed	Children’s Hospital Medical Center, Cincinnati	2019-07-22
NCT03006874	Study to Confirm the Safety and Efficacy of CJ-12420 in Patients With Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT03006874	Completed	CJ HealthCare Corporation	2017-03-24
NCT02881372	EoE Food Desensitization	https://ClinicalTrials.gov/show/NCT02881372	Recruiting	The University of Texas Health Science Center, Houston	2020-05-31
NCT02778867	SOFEED: Six Food vs. One Food Eosinophilic Esophagitis Diet Study	https://ClinicalTrials.gov/show/NCT02778867	Completed	Children’s Hospital Medical Center, Cincinnati	2019-04-17
NCT02755753	A Study to Evaluate REbamiPide as an Adjuvant Regimen to Heal erosIve Reflux Esophagitis	https://ClinicalTrials.gov/show/NCT02755753	Completed	Severance Hospital	2016-01-31
NCT02736409	An Extension Study to Evaluate Maintenance of Efficacy and Long-term Treatment Effect of Oral Budesonide Suspension (OBS) in Adults and Adolescents With Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT02736409	Completed	Shire	2019-11-04
NCT02722148	Application of a Novel Allergen-Specific Immune Signature Directed Approach to Dietary Elimination Therapy in Patients With Eosinophilic Esophagitis (IDiET)	https://ClinicalTrials.gov/show/NCT02722148	Completed	University of North Carolina, Chapel Hill	2018-04-30
NCT02610816	Eosinophilic Esophagitis Intervention Trial-1 Food vs. 4 Food Elimination Diet Followed by Swallowed Glucocorticoids	https://ClinicalTrials.gov/show/NCT02610816	Completed	Children’s Hospital Medical Center, Cincinnati	2018-05-16
NCT02605837	A Study in Adolescents and Adults With Eosinophilic Esophagitis (EoE) Measuring Histologic Response and Determine if Reduction in Dysphagia is Achieved	https://ClinicalTrials.gov/show/NCT02605837	Completed	Shire	2019-01-24
NCT02599558	Cytosponge and Dietary Therapy in EoE	https://ClinicalTrials.gov/show/NCT02599558	Recruiting	Mayo Clinic	2020-12-31
NCT02577393	Study of Epigallocatechin-3-gallate (EGCG) for Esophagus Protection in Patients With Lung Cancer Receiving Radial Radiotherapy	https://ClinicalTrials.gov/show/NCT02577393	Enrolling by invitation	Shandong Cancer Hospital and Institute	2022-06-30
NCT01733147	Modulation of Esophageal Inflammation in Barrett’s Esophagus by Omega-3 Fatty Acids	https://ClinicalTrials.gov/show/NCT01733147	Active, not recruiting	Mayo Clinic	2021-01-31
NCT03388047	Feasibility of Multi-Spectral Endoscopic Imaging for Detection of Early Neoplasia in Barrett’s Oesophagus	https://ClinicalTrials.gov/show/NCT03388047	Recruiting	University of Cambridge	2020-12-31
NCT02028663	Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT02028663	Completed	CJ HealthCare Corporation	2014-05-31
NCT02513784	Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome	https://ClinicalTrials.gov/show/NCT02513784	Completed	Columbia University	2017-12-31
NCT02493335	Maintenance of Remission With Budesonide Orodispersible Tablets vs. Placebo in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02493335	Active, not recruiting	Dr. Falk Pharma GmbH	2018-11-28
NCT02463643	To Evaluate Efficacy and Safety of Z-215 in Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT02463643	Completed	Zeria Pharmaceutical	2016-10-31
NCT02456935	Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT02456935	Completed	CJ HealthCare Corporation	2016-07-31
NCT02388724	Efficacy and Safety of Oral Once-Daily Vonoprazan (TAK-438) in Participants With Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT02388724	Completed	Takeda	2017-07-27
NCT02379052	Study of Dupilumab in Adult Participants With Active Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT02379052	Completed	Regeneron Pharmaceuticals	2017-02-17
NCT02353078	The Effect of Sucralfate Slurry in Patients With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02353078	Completed	Mayo Clinic	2016-12-31
NCT02280616	Budesonide Effervescent Tablets vs. Viscous Budesonide Suspension vs. Placebo in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02280616	Completed	Dr. Falk Pharma GmbH	2013-04-30
NCT02227836	Value of Patch Testing in Direct Diet Therapy for Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02227836	Completed	Mayo Clinic	2017-09-30
NCT02204150	Study to Image the Esophagus Using the OFDI Capsule	https://ClinicalTrials.gov/show/NCT02204150	Completed	Massachusetts General Hospital	2015-07-31
NCT02202590	Using Spectrally Encoded Confocal Microscopy (SECM) to Image the Esophagus	https://ClinicalTrials.gov/show/NCT02202590	Active, not recruiting	Massachusetts General Hospital	2021-12-31
NCT02153398	A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases	https://ClinicalTrials.gov/show/NCT02153398	Completed	AstraZeneca	2016-04-30
NCT02141711	TAK-438 - Safety, Blood Levels & Effects of Repeated Doses	https://ClinicalTrials.gov/show/NCT02141711	Completed	Takeda	2009-02-28
NCT02125851	Comparison of Esophageal Clearance Times of Oral Budesonide Preparations	https://ClinicalTrials.gov/show/NCT02125851	Completed	Walter Reed National Military Medical Center	2014-02-28
NCT02098473	Dose Ranging Study of RPC4046 in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02098473	Completed	Celgene	2016-02-17
NCT02096458	Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets	https://ClinicalTrials.gov/show/NCT02096458	Completed	Takeda	2014-02-28
NCT02038894	Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies	https://ClinicalTrials.gov/show/NCT02038894	Completed	Children’s Hospital Medical Center, Cincinnati	2013-11-30
NCT02019758	Budesonide Versus Fluticasone for Treatment of Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02019758	Completed	University of North Carolina, Chapel Hill	2018-05-31
NCT01999439	EoE(Eosinophilic Esophagitis)	https://ClinicalTrials.gov/show/NCT01999439	Completed	University of Michigan	2016-04-30
NCT01964131	BE Study Between a Capsule and a Sachet Formulation of D961H by Pharmacodynamics in Japanese Healthy Male Subjects	https://ClinicalTrials.gov/show/NCT01964131	Completed	AstraZeneca	2013-12-31
NCT01953575	Mucosal Impedance and Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT01953575	Completed	Mayo Clinic	2019-06-10
NCT01952847	Randomized Trial of Glutamine in Patients With Mucositis or Esophagitis	https://ClinicalTrials.gov/show/NCT01952847	Active, not recruiting	M.D. Anderson Cancer Center	2020-12-31
NCT01874535	Rate of Complete Symptom Relief, Prevention of Symptom Relapse: Grades A and B Esophagitis of Esomeprazole Therapy	https://ClinicalTrials.gov/show/NCT01874535	Completed	Chang Gung Memorial Hospital	2016-06-30
NCT01860482	The Study to Evaluate Efficacy and Safety of Newrabell® Tab.(Rabeprazole Sodium) 10mg b.i.d in Refractory GERD	https://ClinicalTrials.gov/show/NCT01860482	Completed	Chong Kun Dang Pharmaceutical	2015-05-31
NCT01846962	Dietetic Versus Topical Steroids for Pediatric Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT01846962	Completed	Azienda Policlinico Umberto I	2013-04-30
NCT01733810	The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis	https://ClinicalTrials.gov/show/NCT01733810	Completed	Dallas VA Medical Center	2015-07-31
NCT01696734	Domperidone in Treating Patients With Gastrointestinal Disorders	https://ClinicalTrials.gov/show/NCT01696734	Recruiting	M.D. Anderson Cancer Center	2021-10-31
NCT01669811	Compare D961H 20 mg Bid and 20 mg qd in Patients With Refractory Reflux Esophagitis (Inflammation of Lower Esophagus)	https://ClinicalTrials.gov/show/NCT01669811	Completed	AstraZeneca	2014-05-31
NCT01642615	Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules for Healing of Erosive Esophagitis and Maintenance of Healed Erosive Esophagitis and Relief of Heartburn in Adolescents	https://ClinicalTrials.gov/show/NCT01642615	Completed	Takeda	2014-11-30
NCT01642212	OBS in Adolescent and Adults With EOE: A Phase II, Randomized, Double-Blind, Placebo Controlled, Study With an Open Label Extension	https://ClinicalTrials.gov/show/NCT01642212	Completed	Shire	2014-10-30
NCT01641913	Intestinal Permeability in Response to Treatment in Eosinophilic Esophagitis Patients	https://ClinicalTrials.gov/show/NCT01641913	Completed	Mayo Clinic	2014-01-31
NCT01630746	A Randomized, Double-Blind, Multicenter Study to Evaluate the Acid-inhibitory and Dose-response Efficacy of TAK-438 (20 mg, 40 mg) in Patients With Proton Pump Inhibitor (PPI) - Resistant Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT01630746	Completed	Takeda	2013-09-30
NCT01599858	Effect of Repeated Doses of YF476, Omeprazole and Placebo on Stomach Acidity in Healthy Volunteers	https://ClinicalTrials.gov/show/NCT01599858	Completed	Trio Medicines Ltd.	1996-10-31
NCT01585103	Cytosponge Protocol IRB 11-006429	https://ClinicalTrials.gov/show/NCT01585103	Recruiting	Mayo Clinic	2021-09-30
NCT01538849	Study to Investigate the Safety, Tolerability and Efficacy of YH4808 in Patients With Reflux Esophagitis	https://ClinicalTrials.gov/show/NCT01538849	Completed	Yuhan Corporation	2013-11-30
NCT01538797	Effect of Single Doses of YF476 on Stomach Acidity Compared With Ranitidine and Placebo in Fasted and Fed States	https://ClinicalTrials.gov/show/NCT01538797	Completed	Trio Medicines Ltd.	1996-08-31
NCT01538784	Safety, Tolerability and Pharmacokinetics of Single Rising Doses of YF476, a Gastrin Antagonist, in Healthy Men	https://ClinicalTrials.gov/show/NCT01538784	Completed	Trio Medicines Ltd.	1996-06-30
NCT01509261	Efficacy Study of Ilaprazole to Treat Erosive Esophgitis	https://ClinicalTrials.gov/show/NCT01509261	Completed	Il-Yang Pharm. Co., Ltd.	2011-06-30
NCT01499368	A Multi-center, Randomized, Double-blind Phase III Clinical Trial to Assess and Compare to the Efficacy and Safety of Lafutidine, Famotidine and Omeprazole-referenced in Korean Erosive Esophagitis Patients	https://ClinicalTrials.gov/show/NCT01499368	Completed	Boryung Pharmaceutical Co., Ltd	2012-11-30
NCT01459367	Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Maintenance Treatment of Healed Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT01459367	Completed	Takeda	2013-03-31
NCT01452698	Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT01452698	Completed	Takeda	2012-08-31
NCT01397084	To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole	https://ClinicalTrials.gov/show/NCT01397084	Completed	AstraZeneca	2012-01-31
NCT01386112	Safety and Tolerability Study of Oral EUR-1100 to Treat Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT01386112	Completed	Forest Laboratories	2012-10-31
NCT01381991	The Efficacy of i-Scan for Detecting Reflux Esophagitis	https://ClinicalTrials.gov/show/NCT01381991	Completed	Konkuk University Hospital	2010-11-30
NCT04281108	Efficacy and Safety APT-1011 in Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2)	https://ClinicalTrials.gov/show/NCT04281108	Recruiting	Adare Pharmaceuticals, Inc.	2021-10-31
NCT04255693	Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence	https://ClinicalTrials.gov/show/NCT04255693	Recruiting	Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology	2023-12-31
NCT04225026	Effects of Intravenous GC4419 on the Incidence and Severity of Esophagitis Due to Chemoradiotherapy for Lung Cancer	https://ClinicalTrials.gov/show/NCT04225026	Recruiting	Galera Therapeutics, Inc.	2021-12-31
NCT04171986	Mecapegfilgrastim Prevents Neutropenia and Radiation Esophagitis	https://ClinicalTrials.gov/show/NCT04171986	Recruiting	Tianjin Medical University Cancer Institute and Hospital	2021-10-31
NCT04149470	Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis Assessed by Transnasal Endoscopy (TNE)	https://ClinicalTrials.gov/show/NCT04149470	Recruiting	University of Colorado, Denver	2021-12-31
NCT04124926	Efficacy and Safety of Vonoprazan Compared to Lansoprazole in Participants With Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT04124926	Recruiting	Phathom Pharmaceuticals, Inc.	2021-07-01
NCT04070677	Clinical Study Assessing the Effect of ZIVEREL® in Cancer Patients	https://ClinicalTrials.gov/show/NCT04070677	Recruiting	Grupo de Investigación Clínica en Oncología Radioterapia	2020-09-30
NCT04069429	Radiation Dose in Humans From Orally Administered Tc99m-Heparin	https://ClinicalTrials.gov/show/NCT04069429	Recruiting	University of Utah	2020-12-31
NCT03245840	Continuation Study With Budesonide Oral Suspension (BOS) for Adolescent and Adult Subjects With Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT03245840	Active, not recruiting	Shire	2021-08-31
NCT04022096	Study to Confirm the Safety and Efficacy of Tegoprazan in Patients With Healed Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT04022096	Recruiting	CJ HealthCare Corporation	2020-12-31
NCT03781596	EoE RCT Fluticasone and Omeprazole vs Fluticasone Alone	https://ClinicalTrials.gov/show/NCT03781596	Recruiting	Walter Reed National Military Medical Center	2020-10-02
NCT03736369	Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Erosive Gastroesophageal Reflux Disease (Phase 3)	https://ClinicalTrials.gov/show/NCT03736369	Completed	Daewoong Pharmaceutical Co. LTD.	2019-08-07
NCT03657771	A Food Additive Removal Diet for Pediatric Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT03657771	Recruiting	Nemours Children’s Clinic	2020-09-30
NCT03656380	Mepo for EoE Study	https://ClinicalTrials.gov/show/NCT03656380	Recruiting	University of North Carolina, Chapel Hill	2020-12-31
NCT03446118	MRI to Assess Fibrosis in Eosinophilic Esophagitis Patients	https://ClinicalTrials.gov/show/NCT03446118	Recruiting	Mayo Clinic	2021-01-15
NCT03415451	Explore the Efficiency of Fiberscope-guided Nasogastric Tube Insertion	https://ClinicalTrials.gov/show/NCT03415451	Completed	National Taiwan University Hospital	2018-07-30
NCT01262560	Manuka Honey in Preventing Esophagitis-Related Pain in Patients Receiving Chemotherapy and Radiation Therapy For Lung Cancer	https://ClinicalTrials.gov/show/NCT01262560	Completed	Radiation Therapy Oncology Group	2014-02-28
NCT01093755	Does Intensive Acid Suppression Reduce Esophageal Inflammation and Recurrent Barrett’s Esophagus Following Ablation?	https://ClinicalTrials.gov/show/NCT01093755	Completed	Mayo Clinic	2014-11-30
NCT01056783	Proof of Concept Study of OC000459 in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT01056783	Completed	Oxagen Ltd	2011-06-30
NCT01040598	Identifying Responders to Xolair (Omalizumab) Using Eosinophilic Esophagitis as a Disease Model	https://ClinicalTrials.gov/show/NCT01040598	Completed	O & O Alpan LLC	2011-12-31
NCT01022970	Efficacy and Safety of QAX576 in Patients With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT01022970	Completed	Novartis	2012-02-29
NCT01016223	A Randomized Double Blind Placebo Controlled Study of the Effect of Swallowed Beclomethasone Dipropionate on Inflammatory Markers in Adult Patients With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT01016223	Completed	Penn State University	2012-07-31
NCT01008696	An Efficacy Study to Compare the Treatment Effects of Rabeprazole and Lansoprazole Depending on the Genotyping of CYP2C19 in Treating Reflux Esophagitis	https://ClinicalTrials.gov/show/NCT01008696	Completed	Janssen Korea, Ltd., Korea	2008-08-31
NCT00961233	Topical Budesonide Treatment for Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT00961233	Completed	University of North Carolina, Chapel Hill	2011-08-31
NCT00895817	Fluticasone Versus Esomeprazole to Treat Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00895817	Completed	Walter Reed Army Medical Center	2010-10-31
NCT00880906	Study of the Efficiency of Esophageal Dilation on Patient With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00880906	Completed	Vanderbilt University Medical Center	2013-12-31
NCT00872755	Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD)	https://ClinicalTrials.gov/show/NCT00872755	Completed	G. Hatzikosta General Hospital	2008-04-30
NCT03615677	Efficacy and Safety of LXI-15028 Comparing With Esomeprazole in the Treatment of Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT03615677	Completed	Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.	2019-10-18
NCT02995239	A Study to Compare the Pharmacokinetic Characteristics of CJ-12420	https://ClinicalTrials.gov/show/NCT02995239	Completed	CJ HealthCare Corporation	2015-04-30
NCT02679508	Vonoprazan Study in Patients With Erosive Esophagitis to Evaluate Long-term Safety	https://ClinicalTrials.gov/show/NCT02679508	Active, not recruiting	Takeda	2022-02-28
NCT02579876	Milk Patch for Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02579876	Completed	Children’s Hospital of Philadelphia	2017-12-20
NCT02434029	Budesonide Orodispersible Tablet vs. Placebo in Active Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02434029	Completed	Dr. Falk Pharma GmbH	2016-08-04
NCT02388737	Efficacy and Safety of Vonoprazan Compared to Lansoprazole in the Maintenance Treatment of Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT02388737	Completed	Takeda	2018-12-24
NCT02371941	Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02371941	Completed	University of Tennessee	2017-07-31
NCT01452776	Long-Term Safety Study of TAK-438 in the Maintenance Treatment of Healed Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT01452776	Completed	Takeda	2013-07-31
NCT04252144	Study of Dietary Patterns and Food Diversity in Russian GERD Patients	https://ClinicalTrials.gov/show/NCT04252144	Recruiting	Russian Academy of Medical Sciences	2022-09-30
NCT00770913	Double-blind Comparative Study of E3810 Tablets (10 or 20 mg b.i.d.) to Evaluate Efficacy and Safety in Patients With Refractory Reflux Esophagitis	https://ClinicalTrials.gov/show/NCT00770913	Completed	Eisai Inc.	2009-11-30
NCT00762073	Dose-Ranging Study of Oral Viscous Budesonide in Pediatrics With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00762073	Completed	Shire	2010-04-30
NCT00728481	The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00728481	Completed	Mayo Clinic	2010-12-31
NCT02100189	Esophageal Cytology With FISH in Detecting Esophageal Cancer	https://ClinicalTrials.gov/show/NCT02100189	Completed	OHSU Knight Cancer Institute	2015-12-31
NCT00693225	Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot Study	https://ClinicalTrials.gov/show/NCT00693225	Completed	Mayo Clinic	2010-12-31
NCT00644735	Multicenter, Randomized, Double-Blind, Double-Dummy, Parallel-Group Comparison of the Remission Rates of Once Daily Treatment With Esomeprazole 20mg and Lansoprazole 15mg for 6 Months in Patients Whose EE Has Been Healed	https://ClinicalTrials.gov/show/NCT00644735	Completed	AstraZeneca	2004-01-31
NCT00641602	A Multicenter, Randomized, Double Blind, Double Dummy, Parallel-Group Efficacy Study Comparing 8 Weeks of Treatment With Esomeprazole Magnesium (40mg qd) to Lansoprazole (30mg qd) for the Healing of Erosive Esophagitis in Patients With Moderate or Severe Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00641602	Completed	AstraZeneca	2003-08-31
NCT00638456	Use of Topical Budesonide in the Treatment of Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00638456	Completed	University of California, San Diego	2009-09-30
NCT00635089	Open-Label Extension Study of Reslizumab in Pediatric Subjects With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00635089	Completed	Teva Pharmaceutical Industries	2012-01-31
NCT00634114	Reflux Esophagitis Phase III Study (Maintenance Treatment)	https://ClinicalTrials.gov/show/NCT00634114	Completed	AstraZeneca	NA
NCT00633932	Reflux Esophagitis Phase III Study (Initial Treatment)	https://ClinicalTrials.gov/show/NCT00633932	Completed	AstraZeneca	NA
NCT00538434	Efficacy and Safety Study of Reslizumab to Treat Eosinophilic Esophagitis in Subjects Aged 5 to 18 Years	https://ClinicalTrials.gov/show/NCT00538434	Completed	Teva Pharmaceutical Industries	2009-10-31
NCT00523354	Off Label Use of Infliximab in Adult Patients With Severe Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00523354	Completed	Swiss EE Study Group	2007-09-30
NCT00511316	Trial of Montelukast in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00511316	Completed	Mayo Clinic	2015-09-30
NCT00471094	Safety and Efficacy of Ilaprazole 5, 20 and 40 mg QD and Lansoprazole 30 mg QD on Healing of Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00471094	Completed	Takeda	2007-10-31
NCT00426283	A Study of Flovent in Patients With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00426283	Completed	Children’s Hospital Medical Center, Cincinnati	2013-01-31
NCT00358449	Intravenous Mepolizumab In Children With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00358449	Completed	GlaxoSmithKline	2008-11-25
NCT00321737	Efficacy and Safety of Dexlansoprazole MR Compared to Placebo on Maintaining Healing in Subjects With Healed Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00321737	Completed	Takeda	2007-05-31
NCT00284908	Dose-Effect of S-Tenatoprazole-Na(STU-Na) 30 mg, 60 mg, 90 mg and 120 mg in Healthy Volunteers	https://ClinicalTrials.gov/show/NCT00284908	Completed	STEBA France	2006-11-30
NCT00275561	Topical Steroid Treatment for Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00275561	Completed	Mayo Clinic	2010-04-30
NCT00274703	An Evaluation Of Mepolizumab In Therapy Of Eosinophilic Oesophagitis In Adult Patients	https://ClinicalTrials.gov/show/NCT00274703	Completed	GlaxoSmithKline	2007-03-31
NCT00271349	Budesonide for Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00271349	Completed	Swiss EE Study Group	2008-07-31
NCT00266578	A Study Comparing Swallowed Flovent and Placebo in Patients With Eosinophilic Disorders	https://ClinicalTrials.gov/show/NCT00266578	Completed	Children’s Hospital Medical Center, Cincinnati	2006-11-30
NCT00266565	Anti-Interleukin-5 (IL-5) Study for Hypereosinophilic Syndrome	https://ClinicalTrials.gov/show/NCT00266565	Completed	Children’s Hospital Medical Center, Cincinnati	2012-07-31
NCT00256737	Sopran - Omeprazole Treatment Versus Surgery	https://ClinicalTrials.gov/show/NCT00256737	Completed	AstraZeneca	2005-10-31
NCT00255164	Efficacy and Safety of Dexlansoprazole MR on Maintaining Healing in Subjects With Healed Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00255164	Completed	Takeda	2006-11-30
NCT00255151	Comparison of Dexlansoprazole MR to Placebo on the Ability to Maintain Healing in Subjects With Healed Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00255151	Completed	Takeda	2006-11-30
NCT00251719	Efficacy and Safety of Dexlansoprazole MR and Lansoprazole on Healing of Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00251719	Completed	Takeda	2007-01-31
NCT00251693	Efficacy and Safety of Dexlansoprazole MR and Lansoprazole on Healing of Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00251693	Completed	Takeda	2007-01-31
NCT00229424	Verification Study on Lafutidine in Mild Reflux Oesophagitis - Double Blind Controlled Study With Famotidine -	https://ClinicalTrials.gov/show/NCT00229424	Completed	Taiho Pharmaceutical Co., Ltd.	2006-10-31
NCT00228527	Esomeprazole for Treatment of GERD in Pediatric Patients	https://ClinicalTrials.gov/show/NCT00228527	Completed	AstraZeneca	NA
NCT00206284	A Dose-finding Phase IIb Study With AZD0865 and Esomeprazole in GERD Patients Without Erosive Esophagitis.	https://ClinicalTrials.gov/show/NCT00206284	Completed	AstraZeneca	NA
NCT00206245	A Dose-finding Phase IIb Study With AZD0865 and Esomeprazole in GERD Patients With Erosive Esophagitis.	https://ClinicalTrials.gov/show/NCT00206245	Completed	AstraZeneca	NA
NCT00206180	NEXIUM® in the Treatment of Moderate and Severe Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00206180	Completed	AstraZeneca	NA
NCT00195208	Study Comparing a Pantoprazole Formulation to the Currently Marketed Tablet for GERD and Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00195208	Completed	Wyeth is now a wholly owned subsidiary of Pfizer	2005-11-30
NCT00175045	Intravenous vs Oral Lansoprazole on Gastric Acid Secretion in Subjects With Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00175045	Completed	Takeda	2003-10-31
NCT00133770	Intravenous (IV) Pantoprazole in Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00133770	Completed	Emory University	2006-07-31
NCT00123656	Comparison of Esomeprazole to Aerosolized, Swallowed Fluticasone for Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT00123656	Completed	University of Utah	2006-12-31
NCT00123630	A Pilot Study of the Treatment of Eosinophilic Esophagitis With Omalizumab	https://ClinicalTrials.gov/show/NCT00123630	Completed	University of Utah	2010-01-31
NCT00081315	Subcutaneous Amifostine (Ethyol®) in the Prevention of Radiochemotherapy-Induced Esophagitis and Pneumonitis in Patients With Unresectable Non-Small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT00081315	Completed	MedImmune LLC	NA
NCT00005921	A Study of the Side Effects of L-743,872 in Men With Candidal Esophagitis	https://ClinicalTrials.gov/show/NCT00005921	Completed	NIH AIDS Clinical Trials Information Service	NA
NCT00002041	Evaluation of Amphotericin B in the Treatment of Biopsy Proven Candida Esophagitis in Immunocompromised Patients	https://ClinicalTrials.gov/show/NCT00002041	Completed	Bristol-Myers Squibb	NA

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03312686	Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study	https://ClinicalTrials.gov/show/NCT03312686	Recruiting	Indiana University	2018-12-31
NCT03214952	Drug Use Surveillance of Vonoprazan for “Gastric Ulcer, Duodenal Ulcer, and Reflux Esophagitis”	https://ClinicalTrials.gov/show/NCT03214952	Completed	Takeda	2018-10-31
NCT03107819	Metabolomics for Biomarker Discovery in Children With EoE	https://ClinicalTrials.gov/show/NCT03107819	Completed	The University of Texas Health Science Center, Houston	2018-03-31
NCT02995395	Mucosal Impedance Balloon in Diagnosis and Treatment of Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT02995395	Recruiting	Mayo Clinic	2021-01-05
NCT02897271	Characteristics of Eosinophilic Gastritis, Enteritis, and Colitis in a Multi-Site Cohort	https://ClinicalTrials.gov/show/NCT02897271	Active, not recruiting	Children’s Hospital Medical Center, Cincinnati	2019-09-30
NCT02775045	Eosinophil β1 Integrin Activation as a Biomarker for Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02775045	Completed	University of Wisconsin, Madison	2018-12-13
NCT02546219	a4b7 Integrin in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02546219	Completed	Massachusetts General Hospital	2018-12-31
NCT02523118	OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages	https://ClinicalTrials.gov/show/NCT02523118	Recruiting	Children’s Hospital Medical Center, Cincinnati	2050-12-31
NCT02477475	Nexium Capsules S-CEI for Justification of Esomeprazole in Acid Related Disease for Reflux Symptom Healing Based on Patient Clinical Outcomes	https://ClinicalTrials.gov/show/NCT02477475	Completed	AstraZeneca	2017-02-20
NCT02453126	Fibrostenotic Eosinophilic Esophagitis: Assessment Tools	https://ClinicalTrials.gov/show/NCT02453126	Recruiting	University of Colorado, Denver	2020-06-30
NCT02320981	Mucosal Impedance in Pediatric Population	https://ClinicalTrials.gov/show/NCT02320981	Completed	Vanderbilt University Medical Center	2016-09-30
NCT02190513	Prevalence of Eosinophilic Esophagitis in Children With Celiac Disease	https://ClinicalTrials.gov/show/NCT02190513	Completed	St. John Health System, Michigan	2013-06-30
NCT02072590	Improved Diagnostics of Celiac Disease in Children	https://ClinicalTrials.gov/show/NCT02072590	Recruiting	Tampere University Hospital	2022-12-31
NCT01306799	To Learn How Bone Structure and Bone Mass Change After Long-term PPI Use	https://ClinicalTrials.gov/show/NCT01306799	Completed	University of Pennsylvania	2015-04-30
NCT02008903	Esophageal String Test in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02008903	Recruiting	University of Colorado, Denver	2020-06-30
NCT01988285	Risk Factors and Biomarkers for Diagnosis and Treatment of EoE	https://ClinicalTrials.gov/show/NCT01988285	Enrolling by invitation	University of North Carolina, Chapel Hill	2020-08-31
NCT01929824	Nasal Nitric Oxide Levels in Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT01929824	Completed	Mayo Clinic	2017-09-25
NCT01897506	Assessing Risk of Food Insecurity Within Households of Children With Food Allergy	https://ClinicalTrials.gov/show/NCT01897506	Completed	Arkansas Children’s Hospital Research Institute	2015-12-31
NCT01865825	Proton Pump Inhibitor (PPI) Responsive Eosinophilic Esophagitis EoE: Gastroesophageal Reflux Disease (GERD) or Eosinophilic Esophagitis (EoE)?	https://ClinicalTrials.gov/show/NCT01865825	Completed	Mayo Clinic	2016-12-31
NCT01832324	Molecular Basis of Food Allergy	https://ClinicalTrials.gov/show/NCT01832324	Active, not recruiting	Children’s Hospital of Philadelphia	2027-12-31
NCT01631591	Prevalence of Food Allergies in a Cohort of Adult Patients With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT01631591	Completed	University of South Florida	2014-07-31
NCT01562639	Nexium Capsules RE Maintenance Specific Clinical Experience Investigation	https://ClinicalTrials.gov/show/NCT01562639	Completed	AstraZeneca	2014-07-31
NCT01556919	Esophageal Monitoring Device for Assessing Mucosal Impedance	https://ClinicalTrials.gov/show/NCT01556919	Enrolling by invitation	Vanderbilt University Medical Center	2021-06-30
NCT01536080	Analysis of GERD Symptoms Using Gastroesophageal Reflux Impact Score Questionnaire for Quality of Life	https://ClinicalTrials.gov/show/NCT01536080	Completed	Seoul National University Bundang Hospital	NA
NCT01498497	A Six Month, Safety Follow-up Study in Eosinophilic Esophagitis Subjects Who Completed Study PR-021	https://ClinicalTrials.gov/show/NCT01498497	Completed	Forest Laboratories	2013-04-30
NCT01434485	Nexium Capsules Clinical Experience Investigation	https://ClinicalTrials.gov/show/NCT01434485	Completed	AstraZeneca	2014-03-31
NCT01382563	Registry for Eosinophilic Gastrointestinal Disorders (REGID)	https://ClinicalTrials.gov/show/NCT01382563	Active, not recruiting	Children’s Hospital Medical Center, Cincinnati	2050-12-31
NCT01323803	Eosinophilic Esophagitis Databank	https://ClinicalTrials.gov/show/NCT01323803	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	2016-02-29
NCT01322633	Risk of Cancer Among Pantoprazole Users	https://ClinicalTrials.gov/show/NCT01322633	Completed	Pfizer	2013-03-31
NCT01321567	Quality of Life in New Treatable Therapy as Rabeprazole Option for Refractory Reflux Esophagitis	https://ClinicalTrials.gov/show/NCT01321567	Completed	Eisai Inc.	2013-03-01
NCT01921686	Morphological Markers of Gastroesophageal Reflux Disease (GERD)	https://ClinicalTrials.gov/show/NCT01921686	Active, not recruiting	Baylor College of Medicine	2014-09-30
NCT04416217	Eosinophilic Esophagitis Steroid Safety Study	https://ClinicalTrials.gov/show/NCT04416217	Recruiting	Rabin Medical Center	2025-12-31
NCT04309786	Somatization, Anxiety, and Disordered Sleep in Pediatric Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT04309786	Recruiting	University of California, San Diego	2021-04-11
NCT04248296	Evaluate the Intestinal Microbiome in Patients With Erosive Gastroesophageal Reflux Disease and in Asymptomatic Healthy Controls	https://ClinicalTrials.gov/show/NCT04248296	Completed	University of Sao Paulo General Hospital	2019-02-20
NCT03835663	The Bacterial Composition of the Stomach in Reflux Disease	https://ClinicalTrials.gov/show/NCT03835663	Recruiting	Imperial College London	2019-06-01
NCT03615950	Effects of Swallowed Steroids on Bone Density and Growth in Pediatric Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT03615950	Recruiting	Arkansas Children’s Hospital Research Institute	2020-08-01
NCT03581838	Eating With Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT03581838	Completed	Mayo Clinic	2019-07-23
NCT01194323	Biology in Patients With Reflux Esophagitis	https://ClinicalTrials.gov/show/NCT01194323	Completed	Vanderbilt University Medical Center	2012-12-31
NCT01170234	Exhaled Nitric Oxide as a Biomarker of Disease Activity in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT01170234	Completed	Tufts Medical Center	2012-02-29
NCT00920400	Diagnostic Value of Fecal Calprotectin in Disorders of the Upper Gastrointestinal Tract	https://ClinicalTrials.gov/show/NCT00920400	Completed	University Hospital, Basel, Switzerland	2009-09-30
NCT00901004	The Clinical Significance of Minimal Change in Reflux Esophagitis Based on the Gastroesophageal Reflux Disease Questionnaire	https://ClinicalTrials.gov/show/NCT00901004	Completed	AstraZeneca	NA
NCT00859287	Omepral® Tablets Special Clinical Experience Investigation in Patients With Erosive Esophagitis	https://ClinicalTrials.gov/show/NCT00859287	Completed	AstraZeneca	NA
NCT00842387	Evaluation Study of a Management Strategy for Gastroesophageal Reflux Disease (GERD)	https://ClinicalTrials.gov/show/NCT00842387	Completed	AstraZeneca	NA
NCT03214081	Special Drug Use Surveillance of Vonoprazan for “Maintenance Therapy of Reflux Esophagitis: Long-term Use”	https://ClinicalTrials.gov/show/NCT03214081	Completed	Takeda	2018-08-31
NCT03290482	Natural History of Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT03290482	Recruiting	Mayo Clinic	2020-07-01
NCT03812575	The Use of Fractionated Exhaled Nitric Oxide in the Diagnosis and Assessment of Disease Activity of Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT03812575	Recruiting	The University of Texas Health Science Center, Houston	2020-02-28
NCT02434705	Food Antigen in Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT02434705	Recruiting	Mayo Clinic	2021-05-31
NCT01742377	Minimal Change Esophagitis by i-Scan Endoscopy in Dyspeptic Patients	https://ClinicalTrials.gov/show/NCT01742377	Completed	Prince of Songkla University	2014-07-31
NCT03980886	Characteristics and Inflammatory Markers in Children With Eosinophilic Esophagitis (EoE)	https://ClinicalTrials.gov/show/NCT03980886	Recruiting	University of California, San Diego	2028-12-17
NCT00677378	Transient Receptor Potential Vanilloid One (TRPV1) Receptor Expression in Children With Retrosternal Pain	https://ClinicalTrials.gov/show/NCT00677378	Completed	Medical College of Wisconsin	2014-12-31
NCT00667524	Eosinophilic Esophagitis: Influence of Dilation on Dysphagia and Inflammation	https://ClinicalTrials.gov/show/NCT00667524	Completed	University of Bern	2009-03-31
NCT00586963	Proton Pump Inhibitor (PPI) Therapy for Newly Diagnosed Esophagitis	https://ClinicalTrials.gov/show/NCT00586963	Completed	Mayo Clinic	2008-10-31
NCT00579410	Comparison of Acid Reflux at Two Levels in the Esophagus Using the BRAVO Capsule	https://ClinicalTrials.gov/show/NCT00579410	Completed	Kansas City Veteran Affairs Medical Center	2009-10-31
NCT00272818	Study to Identify Non-Invasive Markers of Gastrointestinal Allergy	https://ClinicalTrials.gov/show/NCT00272818	Completed	Boston Children’s Hospital	2008-06-30
NCT00267475	Data Bank for Eosinophilic Disorders	https://ClinicalTrials.gov/show/NCT00267475	Completed	Children’s Hospital Medical Center, Cincinnati	2012-12-31
NCT00256529	Prospective Analysis of Eosinophilic Esophagitis in Patients Presenting With Dysphagia	https://ClinicalTrials.gov/show/NCT00256529	Completed	University of Utah	2011-07-31

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03382678	CEGIR 7807: Validation of Online Cohort of EGID Patients Enrolled in RDCRN CEGIR Contact Registry	https://ClinicalTrials.gov/show/NCT03382678	Enrolling by invitation	Children’s Hospital Medical Center, Cincinnati	2019-08-01
NCT03824431	High Definition Endoscopy With NBI. Contribution in Patients With Non-erosive Esophagitis	https://ClinicalTrials.gov/show/NCT03824431	Completed	University of Sao Paulo General Hospital	2016-11-04
NCT03822325	Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT03822325	Active, not recruiting	Ann & Robert H Lurie Children’s Hospital of Chicago	2015-05-31
NCT04100005	A Pilot Study to Explore the Role of Gut Flora in Crohn’s Disease	https://ClinicalTrials.gov/show/NCT04100005	Recruiting	ProgenaBiome	2023-03-31
NCT03858426	Prospective Multicenter Nationwide Registry of Children With Eosinophilic Esophagitis	https://ClinicalTrials.gov/show/NCT03858426	Recruiting	Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica	2020-11-01
NCT03853772	The Johns Hopkins Heartburn Center Registry	https://ClinicalTrials.gov/show/NCT03853772	Enrolling by invitation	Johns Hopkins University	2025-12-31